Key result
In isolated human atrial myocytes, 5-HT increased L-type calcium current, an effect significantly potentiated in cells from chronically beta-blocked patients (299% vs 220% increase, P<0.05).
Why the study?
Does 5-HT alter electrophysiological properties and arrhythmic activity in isolated human atrial myocytes, and is this influenced by chronic beta-blocker therapy?
Population
Isolated myocytes from the right atrial appendage of 27 consenting patients undergoing cardiac surgery who…
Comparison
5-Hydroxytryptamine (5-HT) (1 nm-10 microm) vs Baseline and comparison between cells from…
Design
Preclinical
Authors
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Hypothesis-generating for 5-HT4-mediated atrial effects; leaves open clinical relevance and need for in vivo trials.
Does 5-HT alter electrophysiological properties and arrhythmic activity in isolated human atrial myocytes, and is this influenced by chronic beta-blocker therapy?
Absolute Event Rate: 299% vs 220%
p-value: p=<0.05
5-HT increases calcium current and prolongs early repolarization in human atrial myocytes, effects that are enhanced by chronic beta-blockade and associated with increased arrhythmic potential.
Pau et al. (2003) studied Patients undergoing cardiac surgery in sinus rhythm (n=27). 5-Hydroxytryptamine (5-HT) in cells from chronically beta-blocked patients vs. Cells from non-beta-blocked patients was evaluated on Maximum increase in L-type Ca2+ current (ICaL) above control (p=<0.05). In isolated human atrial myocytes, 5-HT increased L-type calcium current, an effect significantly potentiated in cells from chronically beta-blocked patients (299% vs 220% increase, P<0.05).
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