Key result
In human isolated atrial myocytes, 1 microM 5-HT caused a positive shift of the If activation curve midpoint by 11.0 +/- 2.0 mV (p < 0.001), an effect prevented by selective 5-HT4 antagonists.
Mean Difference: 11
p-value: p=<0.001
5-HT4 receptor stimulation increases the pacemaker current I(f) in human atrial myocytes, suggesting a potential mechanism for serotonin-induced atrial arrhythmogenesis.
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May promote atrial arrhythmias via I(f) modulation; leaves open whether 5-HT4 antagonists prevent clinical AF.
Pino et al. (1998) studied Patients undergoing coeffective cardiac surgery. Serotonin (5-hydroxytryptamine, 5-HT) vs. Control (baseline) and selective 5-HT4 antagonists was evaluated on Shift of the midpoint (V1/2) of the activation curve of the pacemaker current If (positive shift of 11.0 +/- 2.0 mV, p=<0.001). In human isolated atrial myocytes, 1 microM 5-HT caused a positive shift of the If activation curve midpoint by 11.0 +/- 2.0 mV (p < 0.001), an effect prevented by selective 5-HT4 antagonists.