Key result
I(f) densities were significantly higher and the half maximal activation potential was less negative in left atrial appendage cells (-84.3 mV) compared to left atrial wall cells (-97.8 mV).
Population
Human atrial myocytes isolated from the left atrial appendage and the left atrial wall obtained from…
Comparison
Whole-cell patch-clamp measurement of… vs Comparison between left atrial appendage cells…
Design
Preclinical
Authors
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I(f) in human left atrial myocytes supports mechanistic AF research; leaves open any clinical role or therapeutic targeting.
Absolute Event Rate: -84.3% vs -97.8%
The hyperpolarization-activated cation current (I(f)) is present in human left atrial myocytes, with higher densities in the left atrial appendage, and mathematical modeling suggests it is sufficient to induce spontaneous pacemaker activity contributing to atrial ectopy.
Zorn‐Pauly et al. (2004) studied Patients undergoing open heart surgery. Left atrial appendage (LAA) cells vs. Left atrial wall (LAW) cells was evaluated on Half maximal activation potential (V(1/2)). I(f) densities were significantly higher and the half maximal activation potential was less negative in left atrial appendage cells (-84.3 mV) compared to left atrial wall cells (-97.8 mV).
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