Key result
The hyperpolarization-activated current I(f) was present in all tested left ventricular myocytes from 3 patients with terminal heart failure, with a density of 2.1 +/- 0.3 pA/pF at -120 mV.
Observational (n=3)
The hyperpolarization-activated current I(f) is present in human left ventricular myocytes from failing hearts, suggesting a potential arrhythmogenic mechanism in severe heart failure.
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I(f) in human hypertrophied LVMs may predispose to arrhythmias; hypothesis-generating for targeted therapies in HF.
Cerbai et al. (1997) conducted an observational in Terminal heart failure due to ischemic dilated cardiomyopathy (n=3). Electrophysiological characterization of I(f) was evaluated on Occurrence and electrophysiological properties of I(f). The hyperpolarization-activated current I(f) was present in all tested left ventricular myocytes from 3 patients with terminal heart failure, with a density of 2.1 +/- 0.3 pA/pF at -120 mV.
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