Key result
An If-like current was present in 93% of ventricular myocytes from old hypertensive rats compared to 12.1% from young rats (P<0.01), which may favor spontaneous action potentials.
Population
Left ventricular myocytes isolated from young and old spontaneously hypertensive rats
Comparison
Whole-cell patch-clamp recording in control… vs Young vs old SHRs
Design
Preclinical
Authors
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If-like current may underlie age-related ventricular depolarization in hypertensive models; leaves open its clinical relevance in humans.
Absolute Event Rate: 93% vs 12.1%
p-value: p=< 0.01
An If-like current is significantly upregulated in ventricular myocytes from old spontaneously hypertensive rats, which may contribute to the occurrence of spontaneous action potentials and arrhythmogenesis in hypertensive heart disease.
Cerbai et al. (1994) studied Hypertension (Spontaneously hypertensive rats) (n=60). Old age (18- to 20-month-old) vs. Young age (2-month-old) was evaluated on Presence of a barium-insensitive, caesium-sensitive, time-dependent inward current (If-like current) (p=< 0.01). An If-like current was present in 93% of ventricular myocytes from old hypertensive rats compared to 12.1% from young rats (P<0.01), which may favor spontaneous action potentials.
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