Key result
Levosimendan restored right ventricular-pulmonary arterial coupling better than placebo in a piglet model of pulmonary embolism-induced right ventricular failure.
Why the study?
Does levosimendan improve right ventricular-pulmonary arterial coupling in a piglet model of acute pulmonary embolism-induced right ventricular failure?
Population
14 anesthetized piglets with persistent right ventricular failure induced by repeated acute pulmonary…
Comparison
Levosimendan 20 microg/kg administered in 10… vs Same volumes of isotonic saline
Design
Preclinical, Randomly assigned
Authors
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Hypothesis-generating for levosimendan in acute PE with RV failure; clinical trials needed before any practice change.
RCT (n=14)
randomly assigned
Does levosimendan improve right ventricular-pulmonary arterial coupling in a piglet model of acute pulmonary embolism-induced right ventricular failure?
In a piglet model of pulmonary embolism-induced right ventricular failure, levosimendan improved right ventricular-pulmonary arterial coupling through combined pulmonary vasodilation and increased right ventricular contractility.
Kerbaul et al. (2007) conducted an RCT in acute pulmonary embolism-induced right ventricular failure (n=14). Levosimendan vs. isotonic saline was evaluated on Right ventricular-pulmonary arterial coupling. Levosimendan restored right ventricular-pulmonary arterial coupling better than placebo in a piglet model of pulmonary embolism-induced right ventricular failure.