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January 15, 2002CirculationOpen Access

Role of Myocardial Inducible Nitric Oxide Synthase in Contractile Dysfunction and β-Adrenergic Hyporesponsiveness in Rats With Experimental Volume-Overload Heart Failure

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Key result

Selective iNOS blockade by N-(3-(aminomethyl)benzylacetamidine improved attenuated beta-adrenergic responsiveness in rats with volume-overload heart failure.

Why the study?

Does selective iNOS blockade improve depressed myocardial contractility and beta-adrenergic hyporesponsiveness in rats with volume-overload heart failure?

Population

Rats with volume-overload-induced heart failure, divided into compensated and decompensated subgroups based…

Comparison

Selective iNOS blockade by N-(3-benzylacetamidine vs Control rats and heart failure rats without iNOS…

Design

Preclinical

Authors

OGOlga GealekmanUniversity of Massachusetts Chan Medical SchoolZAZaid AbassiHeart Failure / CardiomyopathyIRIrit RubinsteinTechnion – Israel Institute of Technology

Discussion

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Member takes

Overview

iNOS activation may impair contractility in experimental volume-overload HF; leaves open its role and therapeutic targeting in patients.

Structured PICO

Does selective iNOS blockade improve depressed myocardial contractility and beta-adrenergic hyporesponsiveness in rats with volume-overload heart failure?

P
Population
Rats with volume-overload-induced heart failure by aortocaval fistula, categorized into compensated and decompensated subgroups.
I
Intervention
Selective iNOS blockade by N-(3-(aminomethyl)benzylacetamidine
C
Comparator
Control rats (without heart failure) and heart failure rats without iNOS blockade
O
Outcome
Expression, activity, and localization of eNOS and iNOS, and the effect of iNOS blockade on cardiac contractile properties, intracellular Ca(2+) transients, and beta-adrenergic responsivenesssurrogate

Myocardial iNOS is activated in volume-overload heart failure and its selective blockade improves depressed beta-adrenergic responsiveness.

Cite This Study

Gealekman et al. (2002) studied Volume-overload heart failure. Selective iNOS blockade by N-(3-(aminomethyl)benzylacetamidine vs. Controls / unblocked HF rats was evaluated on Beta-adrenergic responsiveness and myocardial contractility. Selective iNOS blockade by N-(3-(aminomethyl)benzylacetamidine improved attenuated beta-adrenergic responsiveness in rats with volume-overload heart failure.

synapsesocial.com/papers/6a6c48bf34b735385cb3eeddhttps://doi.org/10.1161/hc0202.102015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mice Lacking Inducible Nitric Oxide Synthase Have Improved Left Ventricular Contractile Function and Reduced Apoptotic Cell Death Late After Myocardial Infarction2001 · 157 citations
  2. 2Heterogeneous Basal Expression of Nitric Oxide Synthase and Superoxide Dismutase Isoforms in Mammalian Heart1999 · 83 citations
  3. 3Hormonal determinants of sodium excretion in rats with experimental high-output heart failure1988 · 66 citations
  4. 4Fas (CD95/Apo-1)–Mediated Damage to Ventricular Myocytes Induced by Cytotoxic T Lymphocytes From Perforin-Deficient Mice1998 · 80 citations
  5. 5An inhibitor of nitric oxide synthase does not increase contraction or β-adrenoceptor sensitivity of ventricular myocytes from failing human heart1998 · 27 citations