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June 1, 1995Cardiovascular Research

Selective increase in endothelin-1 and endothelin A receptor subtype in the hypertrophied myocardium of the aorto-venacaval fistula rat

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Key result

In the aortovenocaval fistula rat model of cardiac hypertrophy, there is increased activity of the endothelin system mediated principally by a progressive rise in ET-1 and the ETAR subtype.

Population

Aortovenocaval (AV) fistula rat model of cardiac hypertrophy

Comparison

Aortovenocaval (AV) fistula creation vs Sham operated control rats

Design

Preclinical

Follow-up

up to 35 days

Authors

LBL. BrownHammersmith HospitalDNDiego B. NúñezBrigham and Women's HospitalCBCassandra BrookesUniversity of Leicester

Discussion

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Implication

ET-1/ETAR upregulation in volume-overload hypertrophy; leaves open endothelin role in remodeling and warrants prospective mechanistic studies.

Structured PICO

P
Population
Aortovenocaval (AV) fistula rat model of cardiac hypertrophy
E
Exposure
Aortovenocaval (AV) fistula creation
C
Comparator
Sham operated control rats
O
Outcome
Cardiac mRNA expression of endothelins (ET-1, ET-2, ET-3) and their receptors (ETAR, ETBR), and tissue/plasma concentrations of ET-1surrogate

Cardiac hypertrophy in the AV fistula rat model is characterized by increased activity of the endothelin system, primarily driven by ET-1 and the ETAR subtype.

Cite This Study

Brown et al. (1995) studied Cardiac hypertrophy. Aortovenocaval (AV) fistula vs. Sham operated controls was evaluated on Cardiac mRNA expression of endothelins and their receptors. In the aortovenocaval fistula rat model of cardiac hypertrophy, there is increased activity of the endothelin system mediated principally by a progressive rise in ET-1 and the ETAR subtype.

synapsesocial.com/papers/6a6c48c134b735385cb3eeefhttps://doi.org/10.1016/s0008-6363(96)88611-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered Production of Endothelin-1 in the Hypertrophied Rat Heart1995 · 20 citations
  2. 2Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart1996 · 114 citations
  3. 3Bosentan Attenuates Compensatory Left Ventricular Hypertrophy Induced by Aortocaval Fistula in Rats2005 · 2 citations
  4. 4Cardiac Angiotensin Converting Enzyme and Endothelin Receptor in Rats With Chronic Myocardial Infarction1996 · 13 citations
  5. 5Effects of physiological or pathological pressure load in vivo on myocardial expression of ET-1 and receptors1999 · 30 citations