What is the clinical evidence from this study?

Study design: Other. Population: Neuronal differentiation. Intervention: Angiotensin II. Primary outcome: Nitrite formation and morphological differentiation.

January 1, 1998Endocrine Research

Nitric Oxide, A new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells.

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Key result

Angiotensin II induced morphological differentiation of NG108-15 cells via the AT2 receptor, partly due to an increase in nitric oxide production.

Population

NG108-15 cells

Comparison

Angiotensin II and S-nitroso-N-acetylpenicillamine vs Untreated cells and cells treated with…

Design

Preclinical

Authors

FCFrédéric CôtéUniversité de Sherbrooke LLLiette LaflammeUniversité de Sherbrooke MPMarcel D. PayetUniversité de Sherbrooke

Discussion

Member takes

Implication

Hypothesis-generating for AT2-NO signaling in cell differentiation; should not yet change cardiovascular practice.

Structured PICO

Population

NG108-15 cells

Intervention

Angiotensin II (Ang II) and S-nitroso-N-acetylpenicillamine (SNAP, an exogenous source of NO)

Comparator

Untreated cells and cells treated with N-nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor)

Outcome

Nitrite formation and morphological differentiation (neurite outgrowth)surrogate

Angiotensin II induces morphological differentiation of NG108-15 cells partly through increased nitric oxide production via the AT2 receptor.

Cite This Study

Côté et al. (1998) studied Neuronal differentiation. Angiotensin II was evaluated on Nitrite formation and morphological differentiation. Angiotensin II induced morphological differentiation of NG108-15 cells via the AT2 receptor, partly due to an increase in nitric oxide production.

synapsesocial.com/papers/6a6c55b0050bc01bbbcbaa17 https://doi.org/10.3109/07435809809032622

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Nitric Oxide, A new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric Oxide, A new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider