Key result
Nitric oxide generation significantly decreased angiotensin II receptor binding in rat vascular smooth muscle cells in vitro through a cGMP-independent mechanism (P < 0.05).
p-value: p=< 0.05
Nitric oxide downregulates angiotensin II receptors in vascular smooth muscle cells via a cGMP-independent mechanism.
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Hypothesis-generating for NO-angiotensin receptor crosstalk; leaves open in vivo relevance and therapeutic translation.
Cahill et al. (1995) studied this question. Nitric oxide-generating drugs and lipopolysaccharide was evaluated on [125I]-angiotensin II binding to cells (p=< 0.05). Nitric oxide generation significantly decreased angiotensin II receptor binding in rat vascular smooth muscle cells in vitro through a cGMP-independent mechanism (P < 0.05).
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