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June 30, 1997FEBS Letters

Direct action of nitric oxide on osteoblastic differentiation

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Key result

Nitric oxide donors dose-dependently elevated alkaline phosphatase activity and osteocalcin gene expression, suggesting NO directly facilitates osteoblastic differentiation.

Population

Cultured mouse osteoblasts

Design

Preclinical

Authors

HHHisako HikijiKyushu Dental UniversityWSWee Soo ShinBrigham and Women's HospitalSOShinichiro OidaTsurumi University

Discussion

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Implication

No change to clinical practice; leaves open whether NO promotes osteoblast activity in humans.

Structured PICO

P
Population
Cultured mouse osteoblasts
I
Intervention
Nitric oxide (NO) donors (sodium nitroprusside and NONOate), Interleukin-1beta, tumor necrosis factor-alpha, and L-NMMA
O
Outcome
Alkaline phosphatase (AIPase) activity and expression of osteocalcin genesurrogate

Nitric oxide directly facilitates osteoblastic differentiation in cultured mouse osteoblasts.

Cite This Study

Hikiji et al. (1997) studied this question. Nitric oxide (NO) donors (sodium nitroprusside and NONOate) was evaluated on Alkaline phosphatase (AIPase) activity and expression of osteocalcin gene. Nitric oxide donors dose-dependently elevated alkaline phosphatase activity and osteocalcin gene expression, suggesting NO directly facilitates osteoblastic differentiation.

synapsesocial.com/papers/6a6c55b0050bc01bbbcbaa19https://doi.org/10.1016/s0014-5793(97)00597-8
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Also Consider

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  1. 1Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase1995 · 542 citations
  2. 2Autocrine and paracrine effects of endothelium-derived relaxing factor on intracellular Ca2+ of endothelial cells and vascular smooth muscle cells. Identification by two-dimensional image analysis in coculture.1992 · 43 citations
  3. 3cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells1996 · 123 citations
  4. 4cDNA cloning of alkaline phosphatase from rat osteosarcoma (ROS 17/2.8) cells1987 · 106 citations
  5. 5Effect of a continuously applied compressive pressure on mouse osteoblast‐like cells (MC3T3‐E1) in vitro1990 · 145 citations