Population
Mouse calvarial organ cultures
Comparison
Cytokines, NO synthase inhibitor, and NO donor vs Control cultures and individual cytokines
Design
Preclinical
Authors
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Biphasic NO effects on resorption warrant caution in cytokine therapies; leaves open translation to human bone disease.
Cytokine-induced nitric oxide production exhibits biphasic effects on bone resorption in mouse calvarial cultures, with high levels inhibiting and low levels stimulating resorption.
Ralston et al. (1995) studied this question.
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