Key result
Collateral blood flow increased between 20 seconds and 5 minutes after acute coronary artery occlusion in conscious dogs, with levels at 5 minutes determining subsequent necrosis.
Population
42 conscious dogs undergoing acute circumflex coronary artery occlusion
Comparison
Measurement of collateral blood flow at various… vs Baseline (before occlusion)
Design
Preclinical
Follow-up
48 hours
Authors
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Hypothesis-generating for collateral thresholds in experimental AMI; leaves open translation to human reperfusion decisions.
In a canine model of acute myocardial infarction, collateral blood flow increases within 5 minutes of occlusion, and this early flow level determines the development of subsequent necrosis.
Jugdutt et al. (1979) studied Acute coronary artery occlusion / Myocardial infarction (n=42). Acute coronary artery occlusion was evaluated on Collateral blood flow and subsequent necrosis. Collateral blood flow increased between 20 seconds and 5 minutes after acute coronary artery occlusion in conscious dogs, with levels at 5 minutes determining subsequent necrosis.
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