Key result
Dilated cardiomyopathy was associated with higher regional wall stress and lower percent area changes compared to normal controls.
Why the study?
Is regional wall stress increased and correlated with regional hypokinesis in patients with dilated cardiomyopathy compared to normal controls?
Observational (n=28)
Is regional wall stress increased and correlated with regional hypokinesis in patients with dilated cardiomyopathy compared to normal controls?
Excessive regional afterload (wall stress) is significantly elevated in dilated cardiomyopathy and correlates with regional hypokinesis, suggesting a mechanistic role in ventricular dysfunction.
Answers are grounded in this paper and cite their sources.
Supports mechanistic role of regional wall stress in DCM hypokinesis; hypothesis-generating for afterload-targeted interventions.
Left ventriculography with simultaneous pressure micromanometry was performed in 11 normal control subjects and 17 patients with dilated cardiomyopathy (DCM). Left ventricular silhouettes in the right anterior oblique projection were divided into eight areas, and regional wall stress was computed by Janz's method in each area excluding the two most basal areas. Wall stress was higher in DCM patients than in control subjects (p less than 0.01). The percent area changes from end diastole to end systole in each area were lower in DCM patients than in control subjects (mean for six areas, 22 +/- 14% versus 54 +/- 9%, respectively, p less than 0.01), but the coefficient of variation for the percent area changes in the six areas of the left ventricle in DCM patients was greater than that in control subjects (32 +/- 17% versus 15 +/- 4%, respectively, p less than 0.01), indicating regional differences in hypokinesis. There was a significant negative correlation between end-systolic regional wall stress and percent area change (r = -0.60 to -0.86, p less than 0.05) in each area. Thus, excessive regional afterload may play an important role in causing regional hypokinesis in DCM.
No takes yet. Share an insight, caveat, or question.
Hayashida et al. (1990) conducted an observational in Dilated cardiomyopathy (n=28). Dilated cardiomyopathy vs. Normal control subjects was evaluated on Percent area changes from end diastole to end systole (p=<0.01). Dilated cardiomyopathy was associated with higher regional wall stress and lower percent area changes compared to normal controls.
Synapse has enriched 10 related papers. Consider them for comparative context: