Why the study?
Does patient-specific finite element analysis reveal differences in myocardial wall mechanics between patients with dilated cardiomyopathy and normal controls?
Does patient-specific finite element analysis reveal differences in myocardial wall mechanics between patients with dilated cardiomyopathy and normal controls?
Patient-specific finite element analysis demonstrates increased end-systolic wall stress and reduced myocardial contractility in dilated cardiomyopathy, highlighting its potential utility in assessing progressive ventricular deterioration.
May aid DCM mechanics assessment; hypothesis-generating for clinical use pending prospective validation.
Dilated cardiomyopathy is a heart disease characterized by both left ventricular dilatation and left ventricular systolic dysfunction, leading to cardiac remodeling and ultimately heart failure. We aimed to investigate the effect of dilated cardiomyopathy on the pump performance and myocardial wall mechanics using patient-specific finite element analysis. Results evinced pronounced end-systolic wall stress on left ventricular wall of patients with dilated cardiomyopathy as compared to that of normal hearts. In dilated cardiomyopathy, both end-diastolic and end-systolic pressure-volume relationships of left ventricle and right ventricle were shifted to the right compared to controls, suggesting reduced myocardial contractility. We hereby propose that finite element analysis represents a useful tool to assess the myocardial wall stress and cardiac work, which are responsible for progressive left ventricular deterioration and poor clinical course.
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Scardulla et al. (2015) studied this question.
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