Key result
Lower baseline urinary norepinephrine excretion was associated with greater body weight gain (r = -0.38; p = 0.009), and lower epinephrine excretion with central adiposity (r = -0.44; p = 0.003).
Why the study?
Is low sympathoadrenal activity associated with body weight gain and development of central adiposity in Pima Indian men?
Cohort (n=64)
Is low sympathoadrenal activity associated with body weight gain and development of central adiposity in Pima Indian men?
Low sympathetic nervous system activity and low adrenal medulla activity are associated with body weight gain and the development of central adiposity, respectively.
Low sympathoadrenal activity was associated with weight gain; leaves open causal role in obesity and requires prospective trials.
To investigate the possible role of impaired sympathetic nervous system and/or adrenal medullary function in the etiology of human obesity, we studied 64 Pima Indian men (28 +/- 6 years, 101 +/- 25 kg, 34 +/- 9% body fat, mean +/- SD) in whom sympathoadrenal function was estimated at baseline by measurements of 24-hour urinary norepinephrine (NE) and epinephrine (Epi) excretion rates under weight-maintenance conditions. Body weight, body composition (hydrodensitometry), and body fat distribution (waist-to-thigh circumference ratio, W/T) were measured at baseline and follow-up. Follow-up data were available on 44 subjects who gained on average 8.4 +/- 9.5 kg over 3.3 +/- 2.1 years. In these subjects, baseline NE excretion rate, adjusted for its determinants (i.e., fat free mass, fat mass, and W/T), correlated negatively with bodyweight gain (r = -0.38; p = 0.009). Baseline Epi excretion rate correlated negatively with changes in W/T (r = -0.44; p = 0.003). In conclusion, our data show for the first time that a flow sympathetic nervous system activity is associated with body weight gain in humans. Also, a low activity of the adrenal medulla is associated with the development of central adiposity.
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Tataranni et al. (1997) conducted a cohort in Obesity (n=64). Baseline sympathoadrenal function (urinary norepinephrine and epinephrine excretion) was evaluated on Body weight gain (r = -0.38, p=0.009). Lower baseline urinary norepinephrine excretion was associated with greater body weight gain (r = -0.38; p = 0.009), and lower epinephrine excretion with central adiposity (r = -0.44; p = 0.003).
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