Key result
Pulmonary transit time measured by contrast-enhanced ultrasound showed strong agreement with DCE-MRI (10.5±2.4s vs 10.4±2.0s, P=0.88) and correlated moderately to strongly with NT-proBNP.
Why the study?
Does pulmonary transit time measurement by contrast-enhanced ultrasound accurately correlate with DCE-MRI and heart failure severity in patients referred for CRT?
Cross-Sectional (n=20)
No
Does pulmonary transit time measurement by contrast-enhanced ultrasound accurately correlate with DCE-MRI and heart failure severity in patients referred for CRT?
Mean Difference: 0.1
Absolute Event Rate: 10.5% vs 10.4%
p-value: p=0.88
Pulmonary transit time measured by contrast-enhanced ultrasound shows strong agreement with MRI and correlates with NT-proBNP, offering a clinically feasible method to quantify heart failure severity.
PTT-CEUS may offer a feasible alternative to MRI for preload assessment in HF; leaves open its role in guiding therapy.
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Herold et al. (2016) conducted a cross-sectional in Left ventricular dyssynchrony (n=20). Contrast-enhanced ultrasound (CEUS) vs. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was evaluated on Mean pulmonary transit time (PTT) (bias 0.1s, p=0.88). Pulmonary transit time measured by contrast-enhanced ultrasound showed strong agreement with DCE-MRI (10.5±2.4s vs 10.4±2.0s, P=0.88) and correlated moderately to strongly with NT-proBNP.
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