Key result
A pulmonary transit time ≥14 seconds measured by cardiac CT detected pulmonary hypertension in HFrEF patients with 91% sensitivity and 88% specificity (AUC 0.95).
Why the study?
To evaluate the relationships between pulmonary transit time, cardiac function, and pulmonary haemodynamics in HFrEF and explore PTT performance in detecting pulmonary hypertension.
Does computed tomography pulmonary transit time (PTT) accurately detect pulmonary hypertension in patients with HFrEF?
Observational (n=72)
Does computed tomography pulmonary transit time (PTT) accurately detect pulmonary hypertension in patients with HFrEF?
Effect estimate: AUC 0.95 (91% sensitivity, 88% specificity)
Cardiac CT-derived pulmonary transit time is a highly sensitive and specific non-invasive marker for detecting pulmonary hypertension in patients with HFrEF.
PTT may aid PH detection in advanced HFrEF; leaves open whether it improves risk stratification or outcomes.
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Colin et al. (2019) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=72). Pulmonary transit time (PTT) measured by cardiac CT vs. Patients without pulmonary hypertension and controls was evaluated on Detection of pulmonary hypertension (PH) (AUC 0.95 (91% sensitivity, 88% specificity)). A pulmonary transit time ≥14 seconds measured by cardiac CT detected pulmonary hypertension in HFrEF patients with 91% sensitivity and 88% specificity (AUC 0.95).
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