Key result
Isolated titin molecules consist of a single globular head on a long, thin rod of uniform diameter (900 nm), which likely corresponds to the M band anchoring domain.
Population
Isolated titin molecules (TII) purified from chicken breast muscle myofibrils
Design
Preclinical
Authors
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Novel titin visualization extends sarcomere structural maps; leaves open functional roles in cardiac disease.
Isolated titin molecules possess a polar structure with a single globular head that likely anchors to the M band of the sarcomere.
Nave et al. (1989) studied this question. Titin purification and electron microscopy was evaluated on Molecular structure of isolated titin molecules. Isolated titin molecules consist of a single globular head on a long, thin rod of uniform diameter (900 nm), which likely corresponds to the M band anchoring domain.
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