Key result
Action potential duration in neonatal rat ventricle cells is mainly determined by ICa,L, Ieo, and IK1, with no evidence for a delayed rectifier.
The study identifies that action potential duration in neonatal rat ventricular cells is driven by ICa,L, Ieo, and IK1 currents, without a delayed rectifier.
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In vitro neonatal rat data require validation before clinical use; leaves open ionic mechanisms of human ventricular repolarization.
Fermini et al. (1991) studied this question. Ion channel modulators (Ca, Co, 4-aminopyridine, Sr, tetraethylammonium) was evaluated on Action potential duration determinants (ionic currents). Action potential duration in neonatal rat ventricle cells is mainly determined by ICa,L, Ieo, and IK1, with no evidence for a delayed rectifier.
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