Key result
Withdrawal of buprenorphine and midazolam in a 2-year-old girl triggered suspected takotsubo cardiomyopathy, which improved within 2 weeks.
Why the study?
Can withdrawal of buprenorphine and midazolam trigger Takotsubo cardiomyopathy in young children?
Case Report (n=1)
No
Can withdrawal of buprenorphine and midazolam trigger Takotsubo cardiomyopathy in young children?
This case report highlights that Takotsubo cardiomyopathy can occur in young children, potentially triggered by stress or enhanced sympathetic activity from the withdrawal of buprenorphine and midazolam.
Supports awareness of possible takotsubo cardiomyopathy in children after sedative withdrawal; hypothesis-generating for pediatric incidence and recognition.
A 2-year-old Japanese girl had transient left ventricular apical ballooning on echocardiography and ST-segment elevation and T-wave inversion on electrocardiogram after withdrawal of bupirenorphine and midazolam. The findings improved within 2 weeks. There are many case reports of adults with takotsubo cardiomyopathy but none in children. Takotsubo cardiomyopathy is not well known by pediatric cardiologists, so pediatric cases may have been overlooked. Awareness of a phenomenon similar to takotsubo cardiomyopathy, even in young children, may be important.
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Maruyama et al. (2006) conducted a case report in Suspected Takotsubo Cardiomyopathy (n=1). Withdrawal of buprenorphine and midazolam was evaluated on Development of takotsubo cardiomyopathy. Withdrawal of buprenorphine and midazolam in a 2-year-old girl triggered suspected takotsubo cardiomyopathy, which improved within 2 weeks.
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