Key result
Iatrogenic methadone withdrawal triggered by naloxone administration resulted in reversible Takotsubo cardiomyopathy in a 60-year-old man.
Case Report (n=1)
Highlights iatrogenic methadone withdrawal as a potential trigger for Takotsubo cardiomyopathy.
Clinicians should monitor for Takotsubo cardiomyopathy after naloxone in methadone patients; single case leaves association hypothesis-generating.
Takotsubo cardiomyopathy is a syndrome characterized by transient apical ballooning or reversible midventricular systolic dysfunction. Most cases occur in postmenopausal women and are typically triggered by an acute medical illness or emotional or physical stress. Its presentation is highly suggestive of myocardial ischemia, but there is little or no evidence of epicardial coronary artery disease. To our knowledge there are only three reported cases in the literature of Takotsubo cardiomyopathy induced by opioid agonist withdrawal in adults; ours is the first reported case of iatrogenic methadone withdrawal leading to Takotsubo cardiomyopathy.
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Saiful et al. (2011) conducted a case report in Takotsubo cardiomyopathy (n=1). Iatrogenic methadone withdrawal (Naloxone administration) was evaluated on Development of Takotsubo cardiomyopathy. Iatrogenic methadone withdrawal triggered by naloxone administration resulted in reversible Takotsubo cardiomyopathy in a 60-year-old man.
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