Key result
Tapering of anxiolytic medications (clonazepam and fluoxetine) precipitated an episode of takotsubo cardiomyopathy in a 67-year-old woman with a history of anxiodepressive disorder.
Case Report (n=1)
Tapering of anxiolytic medications in patients with anxiety disorders may precipitate stress-induced Takotsubo cardiomyopathy.
Suggests possible risk with anxiolytic tapering in anxiety; single case leaves association hypothesis-generating.
Takotsubo cardiomyopathy is a transient apical ballooning of the left ventricle typically with electrocardiographic changes and enzyme release without evidence of obstructive coronary artery disease. It typically occurs in postmenopausal women and may have a predilection for patients with anxiety disorders. The following is a case in which we believe takotsubo cardiomyopathy was induced by the tapering of antianxiety medications. We feel that health care professionals should be aware of this possibility in such a patient population especially when they have demonstrated cardiovascular symptomatology.
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Lafferty et al. (2017) conducted a case report in Takotsubo cardiomyopathy (n=1). Tapering of anxiolytic medication (clonazepam and fluoxetine) was evaluated on Development of Takotsubo cardiomyopathy. Tapering of anxiolytic medications (clonazepam and fluoxetine) precipitated an episode of takotsubo cardiomyopathy in a 67-year-old woman with a history of anxiodepressive disorder.
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