Key result
This systematic review protocol outlines methods to evaluate individual interventions for improving adherence to treatment, diet, and physical activity in adults with primary hypertension.
Why the study?
Hypertension is linked to non-adherence to therapeutic regimens, worsening prognosis and costs, making it necessary to identify effective individual interventions to improve adherence.
Do individual interventions improve adherence to pharmacological treatment, diet, and physical activity in adults with primary hypertension?
Systematic Review
Do individual interventions improve adherence to pharmacological treatment, diet, and physical activity in adults with primary hypertension?
This protocol outlines a systematic review to evaluate the effectiveness of individual interventions in improving adherence to medication, diet, and physical activity among adults with primary hypertension.
Protocol outlines methods to assess adherence interventions; leaves open which strategies prove effective.
INTRODUCTION: Hypertension is a chronic disease with 31% worldwide prevalence in adults. It has been associated with non-adherence to therapeutic regime with a negative impact on the prognosis of the disease and healthcare-associated costs. So, it is necessary to identify effective interventions to improve adherence among the afflicted population. The objective of this protocol is to describe the methods for a systematic review that will evaluate the effect of individual interventions so as to improve adherence to the prescribed pharmacological treatment, as well as to prescribed diet and physical activity in adults with primary hypertension. METHODS AND ANALYSIS: A systematic search of studies will be conducted in PubMed/MEDLINE, BVS, CINAHL, Embase, Cochrane and Scopus databases. Randomised and non-randomised clinical studies conducted in human beings, published from 1 January 2009 to 13 December 2019, are to be included, in any language. Adherence to pharmacological treatment, diet and physical activity, measured by direct and indirect methods, will be the primary outcome. Two independent reviewers will select relevant studies and will extract the data following the Cochrane's Handbook for Systematic Reviews of Approach and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Methodological quality will be evaluated using the risk-of-bias (RoB) 2 and Risk of Bias in Non-randomised Studies - of Interventions (ROBINS-I) tools. Risk of bias will also be evaluated, and if the criteria are met, a meta-analysis will be finally performed. ETHICS AND DISSEMINATION: Information to be analysed is of a grouped nature, and given that its sources are published studies, no ethics committee approval is required. Results will be published in scientific journals, and in conferences, seminars and symposiums. Copyrights will be addressed by giving due credit through bibliographic references. PROSPERO REGISTRATION NUMBER: CRD42020147655.
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Parra et al. (2020) conducted a systematic review in primary hypertension. Individual interventions to improve adherence was evaluated on Adherence to pharmacological treatment, diet and physical activity. This systematic review protocol outlines methods to evaluate individual interventions for improving adherence to treatment, diet, and physical activity in adults with primary hypertension.
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