Key result
Nitric oxide signaling has ancient evolutionary origins, playing key roles in oxygen delivery and nitrosative stress protection in animals and microbes, as well as defense responses in plants.
Nitric oxide signaling and its interaction with hemoglobin and reactive oxygen species represent an evolutionarily ancient mechanism conserved across animals, plants, and microorganisms for physiological regulation and immune defense.
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Hypothesis-generating at Level 5; leaves open whether findings apply to cardiovascular populations or practice.
Durner et al. (1999) reported a review. Nitric oxide signaling was evaluated. Nitric oxide signaling has ancient evolutionary origins, playing key roles in oxygen delivery and nitrosative stress protection in animals and microbes, as well as defense responses in plants.
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