Key result
Nitric oxide signaling mechanisms expand through discoveries of endogenous protein N-nitrosation and nitro-fatty acids.
Why the study?
New discoveries are expanding the understanding of nitric oxide's roles and signaling mechanisms in mammalian physiology.
Answers are grounded in this paper and cite their sources.
Recent discoveries expand the understanding of nitric oxide signaling in mammalian physiology, highlighting novel posttranslational modifications and bioactive molecules.
New discoveries are expanding our view of the role of nitric oxide (NO) in mammalian physiology by revealing new types, amounts, and fates of molecules modified in vivo by NO and its derivatives, as well as the profound augmentation of some of NO's actions at physiologic levels of O(2). Investigators have identified a new form of endogenous reversible N-nitrosation reactions in vivo, that of proteins; a new class of endogenously nitrated bioactive molecules in vivo, nitro-fatty acids; and the ability of NO-dependent posttranslational modifications to control the half-life and destination of key regulatory proteins.
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Carl Nathan (2004) reported a review. Nitric oxide (NO) was evaluated. Nitric oxide (NO) signaling mechanisms have been expanded by discoveries of endogenous reversible protein N-nitrosation, nitro-fatty acids, and NO-dependent posttranslational modifications.
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