Key result
Nitric oxide-mediated signaling can be broadly classified into classical cGMP-mediated pathways and nonclassical pathways involving nonenzymatic posttranslational modifications.
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This review summarizes two decades of research on nitric oxide signaling, highlighting the distinction between classical cGMP-mediated pathways and nonclassical posttranslational modifications.
For the past 20 years, nitric oxide (NO) has established itself as a gaseous free radical with crucial and unpredicted roles in a wide spectrum of biological functions and organisms. We present here a case whereby NO-mediated signaling can be broadly classified into classical (cGMP-mediated) and nonclassical, the latter mainly alluding to posttranslational modifications related to NO and its interaction with reactive groups in proteins.
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Martı́nez-Ruiz et al. (2008) reported a review. Nitric oxide (NO) was evaluated. Nitric oxide-mediated signaling can be broadly classified into classical cGMP-mediated pathways and nonclassical pathways involving nonenzymatic posttranslational modifications.
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