Key result
Norepinephrine caused a dose-dependent decrease in lumen diameter in all vessel types, whereas only the efferent arteriole responded to angiotensin II.
Population
Isolated interlobular arteries and superficial afferent and efferent arterioles from rabbit kidney
Design
Preclinical
Authors
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Novel rabbit renal microvessel reactivity data; hypothesis-generating and leaves open human translation.
Angiotensin II acts primarily on postglomerular segments of the rabbit renal microcirculation, while preglomerular vessels exhibit a myogenic response to pressure.
Ruth Edwards (1983) studied this question. Norepinephrine and Angiotensin II was evaluated on Lumen diameter changes. Norepinephrine caused a dose-dependent decrease in lumen diameter in all vessel types, whereas only the efferent arteriole responded to angiotensin II.
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