In adults <65 years old, obesity (HR 1.07 per 1 kg/m2) and nocturnal oxygen desaturation (HR 3.29) independently predicted incident atrial fibrillation.
Cohort (n=3,542)
Hazard Ratio: 2.18 (95% CI 1.34–3.54)
OBJECTIVES: This study sought to identify whether obesity and obstructive sleep apnea (OSA) independently predict incident atrial fibrillation/flutter (AF). BACKGROUND: Obesity is a risk factor for AF, and OSA is highly prevalent in obesity. Obstructive sleep apnea is associated with AF, but it is unknown whether OSA predicts new-onset AF independently of obesity. METHODS: We conducted a retrospective cohort study of 3,542 Olmsted County adults without past or current AF who were referred for an initial diagnostic polysomnogram from 1987 to 2003. New-onset AF was assessed and confirmed by electrocardiography during a mean follow-up of 4.7 years. RESULTS: Incident AF occurred in 133 subjects (cumulative probability 14%, 95% confidence interval CI 9% to 19%). Univariate predictors of AF were age, male gender, hypertension, coronary artery disease, heart failure, smoking, body mass index, OSA (hazard ratio 2.18, 95% CI 1.34 to 3.54) and multiple measures of OSA severity. In subjects or =65 years of age. CONCLUSIONS: Obesity and the magnitude of nocturnal oxygen desaturation, which is an important pathophysiological consequence of OSA, are independent risk factors for incident AF in individuals <65 years of age.
Gami et al. (Tue,) conducted a cohort in Obstructive sleep apnea and obesity (n=3,542). Obstructive sleep apnea vs. Absence of obstructive sleep apnea was evaluated on Incident atrial fibrillation/flutter (HR 2.18, 95% CI 1.34-3.54). In adults <65 years old, obesity (HR 1.07 per 1 kg/m2) and nocturnal oxygen desaturation (HR 3.29) independently predicted incident atrial fibrillation.