Key result
Non-alcoholic fatty liver disease was independently associated with increased arterial stiffness in subjects with normal glucose tolerance (mild NAFLD OR 2.02; 95% CI 1.43-2.84), but not in diabetes.
Why the study?
Is non-alcoholic fatty liver disease associated with increased arterial stiffness across different glucose tolerance statuses?
Cross-Sectional (n=4,860)
Is non-alcoholic fatty liver disease associated with increased arterial stiffness across different glucose tolerance statuses?
NAFLD is independently associated with increased arterial stiffness in individuals with normal glucose tolerance, suggesting early vascular risk before the onset of dysglycemia.
Answers are grounded in this paper and cite their sources.
NAFLD severity may associate with arterial stiffness across glucose tolerance spectra; leaves open causal links and need for prospective outcome trials.
AIM: To evaluate the association between non-alcoholic fatty liver disease and arterial stiffness in adults with normal glucose tolerance, pre-diabetes and newly diagnosed diabetes after excluding known diabetes. METHODS: A total of 4860 subjects were divided into normal glucose tolerance, pre-diabetes and newly diagnosed diabetes groups according to the American Diabetes Association 2011 diagnostic criteria. The severity of non-alcoholic fatty liver disease was divided into mild and moderate to severe. Increased arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ⩾ 1400 cm/s. RESULTS: There was a significant difference in the prevalence of mild and moderate to severe non-alcoholic fatty liver disease between subjects with and without increased arterial stiffness. Mild (odds ratio (OR) = 2.02, 95% confidence interval (CI) = 1.43-2.84) and moderate to severe (OR = 2.15, 95% CI = 1.33-3.46) non-alcoholic fatty liver disease were independently associated with increased arterial stiffness in the normal glucose tolerance group. In the pre-diabetes and diabetes groups, neither mild nor moderate to severe non-alcoholic fatty liver disease was associated with increased arterial stiffness. CONCLUSION: The effect of non-alcoholic fatty liver disease on arterial stiffness is apparent in subjects with normal glucose tolerance, but not in diabetes and pre-diabetes.
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Chou et al. (2015) conducted a cross-sectional in Non-alcoholic fatty liver disease and arterial stiffness (n=4,860). Non-alcoholic fatty liver disease vs. No non-alcoholic fatty liver disease was evaluated on Increased arterial stiffness (brachial-ankle pulse wave velocity ≥ 1400 cm/s) (OR 2.02, 95% CI 1.43-2.84). Non-alcoholic fatty liver disease was independently associated with increased arterial stiffness in subjects with normal glucose tolerance (mild NAFLD OR 2.02; 95% CI 1.43-2.84), but not in diabetes.
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