Key result
A higher combined healthy lifestyle score was associated with reduced aortic pulse wave velocity (mean difference -0.113 m/s per unit increment; 95% CI -0.196 to -0.029).
Why the study?
Does a higher combined healthy lifestyle score improve arterial stiffness in older adults?
Observational (n=3,235)
Does a higher combined healthy lifestyle score improve arterial stiffness in older adults?
Mean Difference: -0.113 (95% CI -0.196–-0.029)
Combining multiple healthy lifestyle factors is associated with reduced aortic stiffness, a measure of functional vascular aging, independent of traditional cardiovascular risk factors.
Hypothesis-generating for lifestyle effects on vascular aging; leaves open whether interventions alter arterial stiffness.
OBJECTIVE: To evaluate whether components of a healthy lifestyle, combined and individually, are associated with arterial stiffness as a marker of functional vascular aging. METHODS: We included 3235 participants aged 61-96 years from the Rotterdam Study. Measures of arterial stiffness included: aortic pulse wave velocity and carotid distensibility coefficient. Participants were scored one point for each of healthy lifestyle factors: consumption of five or more of fruits and/or vegetables per day, 75 min or more vigorous physical activity per week, 18.5 ≤ BMI ≤ 24. 9, never smoked and light-to-moderate alcohol intake (maximum seven glasses for women and 14 glasses for men) per week. Also a combined score (0-5) was computed by adding the five factors. Linear regression analysis was used to evaluate the association of healthy lifestyle and measures of arterial stiffness adjusting for confounders. RESULTS: Participants had -0.113 [95% confidence interval (CI): -0.196, -0.029] difference in mean aortic pulse wave velocity m/s per unit increment of the lifestyle factors score, independent of cardiovascular risk factors. Higher fruit and vegetable consumption -0.221 (95% CI: -0.409, -0.034) and physical activity -0.239 (95% CI: -0.433, -0.044) were also significantly associated with reduced aortic pulse wave velocity. The corresponding estimates in carotid distensibility coefficient lacked statistical significance when we adjusted for cardiovascular risk factors. CONCLUSION: Combining multiple healthy lifestyle factors is associated with reduced aortic stiffness, a measure of functional vascular aging and independent of cardiovascular risk factors.
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Karimi et al. (2016) reported an observational. Healthy lifestyle factors score vs. Per unit increment was evaluated on Mean aortic pulse wave velocity (MD -0.113, 95% CI -0.196 to -0.029). A higher combined healthy lifestyle score was associated with reduced aortic pulse wave velocity (mean difference -0.113 m/s per unit increment; 95% CI -0.196 to -0.029).
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