Key result
Pulse pressure progressively increased with type 1 diabetes duration, and this increase was amplified during squatting (50 to 69 mmHg) compared with standing (44 to 55 mmHg).
Why the study?
Does posture (squatting) influence pulse pressure changes according to disease duration in patients with type 1 diabetes?
Cross-Sectional (n=159)
Does posture (squatting) influence pulse pressure changes according to disease duration in patients with type 1 diabetes?
Pulse pressure increases with type 1 diabetes duration, particularly in women, and this increase is amplified by squatting.
Answers are grounded in this paper and cite their sources.
Pulse pressure monitoring by posture may refine risk assessment in long-duration type 1 diabetes; leaves open prospective validation for outcomes.
OBJECTIVE: To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture. RESEARCH DESIGN AND METHODS: We performed continuous measurement of blood pressure with a Finapres device during a 3 x 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (<or=10, 11-20, 21-30, and >30 years, groups 1-4, respectively) and compared the results with those of age-matched nondiabetic subjects. RESULTS: Pulse pressure progressively increased according to type 1 diabetes duration (P < 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulse-pressure increase from group 1 to group 4 was amplified in the squatting position (from 50 +/- 17 to 69 +/- 14 mmHg) compared with standing (from 44 +/- 15 to 55 +/- 12 mmHg). CONCLUSIONS: Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.
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Philips et al. (2008) conducted a cross-sectional in Type 1 diabetes (n=159). Type 1 diabetes duration and squatting posture vs. Shorter diabetes duration, standing posture, and nondiabetic subjects was evaluated on Pulse pressure changes (p=< 0.0001). Pulse pressure progressively increased with type 1 diabetes duration, and this increase was amplified during squatting (50 to 69 mmHg) compared with standing (44 to 55 mmHg).
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