Key result
Contrast-free percutaneous pulmonary valve implantation was technically successful in all patients, significantly reducing mean right ventricular pressure from 60 mmHg to 36 mmHg.
Why the study?
Contrast-induced nephropathy is a real risk for teenagers and adults with CHD undergoing PPVI.
Does contrast-free percutaneous pulmonary valve implantation provide safe and effective hemodynamic improvement in patients with congenital heart disease and RVOT dysfunction?
Observational (n=21)
No
Does contrast-free percutaneous pulmonary valve implantation provide safe and effective hemodynamic improvement in patients with congenital heart disease and RVOT dysfunction?
Answers are grounded in this paper and cite their sources.
INTRODUCTION: Percutaneous pulmonary valve replacement (PPVI) continues to gather pace in pediatric and adult congenital practice. This is fueled by an expanding repertoire of devices, techniques and equipment to suit the heterogenous anatomical landscape of patients with lesions of the right ventricular outflow tract (RVOT). Contrast-induced nephropathy is a real risk for teenagers and adults with congenital heart disease (CHD). AIM: To present a series of patients who underwent PPVI without formal RVOT angiography and propose case selection criteria for patients who may safely benefit from this approach. MATERIAL AND METHODS: We retrospectively collected PPVI data from the preceding 2 years at our institution identifying patients who had been listed as suitable for consideration for contrast-free PPVI from our multidisciplinary team (MDT) meeting based on predefined criteria. Demographic, clinical, imaging and hemodynamic data were collected. Data were analyzed using SPSS. RESULTS: prior to PPVI. One patient had a complication which may have been recognized earlier with post-intervention RVOT contrast injection. CONCLUSIONS: Zero-contrast PPVI is technically feasible and the suitability criteria for those who might benefit are potentially straightforward. The advent of fusion and 3D imaging in cardiac catheterization laboratories is likely to expand our capacity to perform more procedures with less contrast. Patients with bio-prosthetic valves in the pulmonary position may benefit from contrast-free percutaneous pulmonary valve implantation.
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O’Callaghan et al. (2021) conducted an observational in Right ventricular outflow tract dysfunction (n=21). Contrast-free percutaneous pulmonary valve implantation vs. Baseline (pre-intervention) was evaluated on Right ventricular pressure (mmHg) (p=<0.01). Contrast-free percutaneous pulmonary valve implantation was technically successful in all patients, significantly reducing mean right ventricular pressure from 60 mmHg to 36 mmHg.
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