Key result
Male sex, reduced ejection fraction, diabetes, prior myocardial infarction, and high C-reactive protein were the most powerful predictors of cardiovascular events in patients with stable angina.
Why the study?
Which clinical and laboratory variables best predict major adverse cardiac events in patients with stable angina?
Population
104,559 patients with stable angina/stable coronary artery disease from 42 observational studies
Design
Meta-analysis
Follow-up
median 57 months
Authors
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May aid risk stratification in stable angina; leaves open need for prospective validation of these predictors.
Meta-Analysis (n=104,559)
Which clinical and laboratory variables best predict major adverse cardiac events in patients with stable angina?
Simple, low-cost clinical features such as male sex, reduced EF, diabetes, prior MI, and high CRP are powerful predictors of cardiovascular events in patients with stable coronary artery disease.
Barbero et al. (2016) conducted a meta-analysis in stable angina (n=104,559). Clinical and laboratory markers (male sex, reduced EF, diabetes, prior MI, high C-reactive protein) was evaluated on Major adverse cardiovascular event (MACE, a composite endpoint of death, myocardial infarction, and revascularization). Male sex, reduced ejection fraction, diabetes, prior myocardial infarction, and high C-reactive protein were the most powerful predictors of cardiovascular events in patients with stable angina.
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