Key result
The combination of cyclosporin A and dipyridamole prevented the development of graft arteriosclerosis in transplanted rat hearts at 20 and 50 days postoperatively.
Why the study?
Does the combination of cyclosporin A and dipyridamole prevent graft arteriosclerosis in a rat heart transplant model?
Population
Rat heart transplant model
Comparison
Cyclosporin A combined with dipyridamole or… vs Cyclosporin A alone
Design
Preclinical
Follow-up
20 and 50 days postoperatively
Authors
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May warrant adjunctive therapy beyond cyclosporin A post-transplant; leaves open clinical translation of dipyridamole combination from rat models.
Does the combination of cyclosporin A and dipyridamole prevent graft arteriosclerosis in a rat heart transplant model?
In a rat heart transplant model, adding dipyridamole to cyclosporin A prevented the development of immunologically induced graft arteriosclerosis.
Lurie et al. (1981) studied Graft arteriosclerosis in heart transplantation. Cyclosporin A and dipyridamole vs. Cyclosporin A alone; Sulfinpyrazone and cyclosporin A was evaluated on Development of arteriosclerotic-like vessel disease. The combination of cyclosporin A and dipyridamole prevented the development of graft arteriosclerosis in transplanted rat hearts at 20 and 50 days postoperatively.
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