Key result
Gene therapy offers a promising localized treatment approach for arthritis by providing stable, long-term expression of therapeutic genes without the systemic side effects of biologic therapies.
Why the study?
Does gene therapy provide effective and safe treatment for arthritis compared to systemic biologic therapy?
Does gene therapy provide effective and safe treatment for arthritis compared to systemic biologic therapy?
Gene therapy offers a promising, localized approach to arthritis treatment with prolonged efficacy and fewer systemic side effects compared to traditional biologic therapies.
Should not yet change arthritis practice; hypothesis-generating for sustained local effects pending randomized human trials.
Gene therapy can offer a new approach to arthritis treatment which acts at an inflammation site. Numerous studies show high efficacy of gene therapy in different models of arthritis in humans. Even a single injection of a recombinant vector results in a stable prolonged expression of a therapeutic gene and a longterm therapeutic effect. In contrast to biologic therapy involving numerous systemic injections of recombinant anti-inflammatory proteins, gene therapy does not produce systemic side effects. Vectors based on retroviruses, adenoviruses, adeno-associated viruses, and recombinant plasmids could provide delivery of target genes. Of significant importance is the development of noninvasive methods of gene therapy: intranasal and peroral. The current state of research in arthritis gene therapy is discussed in this review.
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Nepomnyashchikh et al. (2016) conducted a review in Arthritis (Rheumatoid Arthritis and Osteoarthritis). Gene therapy vs. Biologic therapy was evaluated. Gene therapy offers a promising localized treatment approach for arthritis by providing stable, long-term expression of therapeutic genes without the systemic side effects of biologic therapies.
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