Key result
Felodipine extended release (10 mg daily) significantly reduced systolic and diastolic blood pressure throughout 24 hours compared to placebo (P<.001).
Why the study?
Does extended release felodipine 10 mg once daily reduce 24-hour ambulatory blood pressure in patients with mild-to-moderate essential hypertension?
RCT (n=12)
Does extended release felodipine 10 mg once daily reduce 24-hour ambulatory blood pressure in patients with mild-to-moderate essential hypertension?
p-value: p=<.001
Extended release felodipine 10 mg once daily effectively lowers 24-hour ambulatory blood pressure and blunts blood pressure spikes during physical stress in patients with mild-to-moderate hypertension.
May support once-daily felodipine ER for 24-h BP control in mild hypertension; leaves open confirmation in larger randomized trials.
Intraarterial blood pressure (BP) monitoring during free ambulation (Oxford technique) was carried out in 12 essential mild-to-moderate hypertensive patients undergoing 4 weeks treatment with felodipine, 10 mg given once daily in an extended release formulation. Compared to placebo, felodipine significantly reduced systolic and diastolic blood pressure throughout 24 h. The greatest reduction was observed at 10 AM, 3 h after drug administration (-32 +/- 6/-24 +/- 5 mm Hg for systolic and diastolic BP, respectively, P less than .001). Hourly BP values remained significantly lower up to and including the 24th hour during felodipine extended release treatment (-18 +/- 5/-11 +/- 3 mm Hg, P less than .001). Felodipine extended release also reduced 24 h blood pressure variability, evaluated on the standard deviation of each hourly mean (from 16.3 +/- 0.9/12.6 +/- 0.6 to 13.4 +/- 0.6/10.4 +/- 0.6 mm Hg, P less than .01). Furthermore, absolute BP values dropped significantly at the peaks of dynamic exercise (bicycle ergometer: from 248 +/- 13/123 +/- 11 to 204 +/- 24/102 +/- 13 mm Hg, P less than .001), isometric exercise (hand grip: from 232 +/- 18/133 +/- 16 to 180 +/- 20/101 +/- 16 mm Hg, P less than .001), and cold pressor test (from 229 +/- 20/127 +/- 14 to 178 +/- 22/99 +/- 15 mm Hg, P less than .001). In conclusion, felodipine extended release exerts a good antihypertensive effect which is maintained for 24 h and reduces the level of blood pressure peaks reached under different physical stresses.
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Fariello et al. (1991) conducted an RCT in essential mild-to-moderate hypertension (n=12). felodipine extended release vs. placebo was evaluated on systolic and diastolic blood pressure throughout 24 h (p=<.001). Felodipine extended release (10 mg daily) significantly reduced systolic and diastolic blood pressure throughout 24 hours compared to placebo (P<.001).
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