March 1, 1994Clinical Pharmacology & Therapeutics
Extended-release felodipine in patients with mild to moderate hypertension
Why the study?
Does once-daily extended-release felodipine reduce blood pressure in patients with mild to moderate hypertension?
Population
286 patients with mild to moderate hypertension who had untreated diastolic blood pressure while seated of…
Comparison
Felodipine extended release once-daily doses of… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
8 weeks
Authors
Discussion
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Implication
Supports once-daily ER felodipine in mild-moderate hypertension; extends RCT evidence for its dose-dependent efficacy.
Structured PICO
Does once-daily extended-release felodipine reduce blood pressure in patients with mild to moderate hypertension?
P
Population
286 patients with mild to moderate hypertension who had untreated diastolic blood pressure while seated of 95 to 115 mm Hg
I
Intervention
Felodipine extended release (ER) once-daily doses of 2.5, 5, or 10 mg
C
Comparator
Placebo
O
Outcome
Mean reduction in diastolic blood pressure after 8 weeks of treatmentsurrogate
Once-daily extended-release felodipine provides dose-dependent, 24-hour reductions in blood pressure for patients with mild to moderate hypertension.
Cite This Study
Weber et al. (1994) studied this question.