Non-Invasive Detection of Coronary Endothelial Response to Sequential Handgrip Exercise in Coronary Artery Disease Patients and Healthy Adults
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Key result
Repeated isometric handgrip exercise did not significantly change MRI measures of coronary endothelial function, including cross-sectional area and blood flow, in CAD patients or healthy adults.
Why the study?
Does repeated isometric handgrip stress change coronary endothelial function measured by 3T MRI in healthy adults and CAD patients?
Population
n=32 adults. Healthy subjects: under age 50 without known history of CAD and traditional risk factors, or…
Comparison
Sequential isometric handgrip stress using an… vs Baseline resting measurements prior to the first…
Design
Cross-sectional
Authors
Discussion
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Implication
Repeated IHG yields reproducible CorEndoFx by MRI in CAD patients and controls; extends feasibility for paired acute intervention studies but requires prospective confirmation.
Study Design
Type
Cross-Sectional (n=32)
Multicenter
No
Structured PICO
Does repeated isometric handgrip stress change coronary endothelial function measured by 3T MRI in healthy adults and CAD patients?
P
Population
32 participants, comprising 20 healthy adults and 12 patients with coronary artery disease, underwent sequential isometric handgrip stress testing with 3.0T MRI to assess coronary endothelial function.
I
Intervention
Sequential isometric handgrip (IHG) stress using an MRI-compatible dynamometer for 4 minutes at 30% of maximum grip strength, repeated after a 10-minute recovery period, with coronary endothelial function measured by 3.0 Tesla MRI.
C
Comparator
Baseline resting measurements prior to the first stress, and comparison of the physiological response between the first and second stress periods.
O
Outcome
Change in coronary cross-sectional area (CSA), peak diastolic coronary flow velocity (PDFV), and coronary blood-flow during repeated isometric handgrip stress.surrogate
Main Result
Absolute Event Rate: 17.8% vs 14.8%
p-value: p=0.24
Non-invasive 3T MRI assessment of coronary endothelial function during isometric handgrip exercise is highly reproducible, supporting its use in future studies evaluating the effects of acute interventions on coronary vasoreactivity.
Limitations
- Did not compare MRI-derived measures of coronary vasoreactivity with invasive methods such as coronary angiography or Doppler guidewire
- Relatively small sample size, particularly in the CAD group
- The healthy and CAD groups were not age-matched
- The two groups were not age-matched
Cite This Study
Hays et al. (2013) conducted a cross-sectional in Coronary Artery Disease (n=32). Sequential isometric handgrip (IHG) stress vs. First IHG stress was evaluated on Percent change in coronary cross-sectional area (CSA) during second versus first isometric handgrip stress in healthy adults (p=0.24). Repeated isometric handgrip exercise did not significantly change MRI measures of coronary endothelial function, including cross-sectional area and blood flow, in CAD patients or healthy adults.
Topics
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