Key result
Doppler ultrasound-derived mean diastolic pressure gradients (average 11.8 mmHg) significantly correlated with catheterization data (average 16.7 mmHg) in patients with mitral stenosis.
Why the study?
Does Doppler ultrasound accurately estimate mean diastolic pressure gradients and mitral valve area compared to catheterization in patients with mitral stenosis?
Observational (n=16)
Does Doppler ultrasound accurately estimate mean diastolic pressure gradients and mitral valve area compared to catheterization in patients with mitral stenosis?
Absolute Event Rate: 11.8% vs 16.7%
Doppler ultrasound provides a reliable, non-invasive method to estimate transmitral pressure gradients and mitral valve area in patients with mitral stenosis.
May support non-invasive MS gradient assessment; leaves open larger validation studies before clinical adoption.
In 16 patients with mitral stenosis (MS), alone or in combination with either mitral insufficiency (2 pats.) or aortic valve disease (3 pats.), the mean diastolic pressure gradients across the mitral valve calculated by Doppler ultrasound were significantly correlated to the catheterization data. The average mean pressure drop by Doppler was 11.8 mmHg and by catheterization at rest 16.7 mmHg. A significant correlation between gradients was also found in 5 patients who exercised supine on a bicycle. Atrioventricular pressure half-time (T1/2), i.e. the time during which the pressure drops from the peak value to half of its initial value by the Doppler technique, was significantly correlated to mitral valve area (MVA) determined from catheterization data. Increasing T1/2 reflected decreasing MVA. It is concluded that Doppler ultrasound is a useful method in the evaluation of patients with MS.
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Knutsen et al. (1982) conducted an observational in Mitral stenosis (n=16). Doppler ultrasound vs. Catheterization was evaluated on Mean diastolic pressure gradients across the mitral valve. Doppler ultrasound-derived mean diastolic pressure gradients (average 11.8 mmHg) significantly correlated with catheterization data (average 16.7 mmHg) in patients with mitral stenosis.
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