Malnutrition indices (PNI, GNRI, and CONUT) independently predicted all-cause mortality in patients with heart failure (P<0.001), with PNI and GNRI showing superior predictive ability over CONUT.
Cohort (n=1,307)
Do nutritional indices (PNI, GNRI, and CONUT) predict all-cause mortality in patients with heart failure?
Malnutrition, as assessed by PNI, GNRI, or CONUT, is an independent predictor of all-cause mortality in heart failure patients, with PNI and GNRI offering superior prognostic value over CONUT.
p-value: p=<0.001
Background: Malnutrition is a common condition that is associated with adverse prognosis in patients with heart failure (HF). The Prognostic Nutritional Index (PNI), Geriatric Nutritional Risk Index (GNRI) and controlling nutritional status (CONUT) have all been used as objective indices for evaluating nutritional status. We aimed to clarify the relationship between these nutritional indices and the parameters of inflammatory markers, cardiac function and exercise capacity, as well as to compare the ability of these indexes for predicting mortality. Methods: We evaluated PNI, GNRI and CONUT in consecutive 1307 patients with HF. Results: (P<0.05, respectively). Second, in the Kaplan-Meier analysis (follow-up 1146 days), all-cause mortality progressively increased from normal to mild, moderate and severe disturbance groups in the indices (log-rank, P<0.01, respectively). In the Cox proportional hazard analysis, each index was an independent predictor of all-cause mortality in patients with HF (P<0.001, respectively). Third, receiver operating curve demonstrated that the areas under the curve of PNI and GNRI were larger than that of CONUT score (P<0.05, respectively). Conclusion: Patients with HF being malnourished had higher mortality accompanied by higher levels of C reactive protein, tumour necrosis factor-α, adiponectin, B-type natriuretic peptide, troponin I, right-sided volume overload and impaired exercise capacity, rather than left ventricular systolic function. Additionally, PNI and GNRI were superior to CONUT score in predicting mortality in patients with HF.
Yoshihisa et al. (Mon,) conducted a cohort in Heart failure (n=1,307). Malnutrition (assessed by PNI, GNRI, and CONUT) vs. Normal nutritional status was evaluated on All-cause mortality (p=<0.001). Malnutrition indices (PNI, GNRI, and CONUT) independently predicted all-cause mortality in patients with heart failure (P<0.001), with PNI and GNRI showing superior predictive ability over CONUT.