Key result
A high dose of propafenone in a suicidal attempt caused a Brugada-type electrocardiographic pattern, highlighting the differential diagnosis of Brugada phenocopies.
Case Report (n=1)
Propafenone overdose can induce a Brugada-type electrocardiographic pattern, highlighting the clinical challenge of distinguishing between true Brugada syndrome and Brugada phenocopies.
Propafenone overdose may induce Brugada-like ECG changes; leaves open distinction from true phenocopy and requires prospective validation.
Brugada syndrome is a form of inherited arrhythmia syndrome characterized by a distinct ST-segment elevation in the right precordial leads. Brugada phenocopies are clinical entities that present with an electrocardiographic pattern identical to Brugada syndrome and may obey to various clinical conditions. We present a case of a suicidal attempt using a high dose of propafenone causing a Brugada-type electrocardiographic pattern. Is this a Brugada syndrome case, a Brugada phenocopy or something else?
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Kocabaş et al. (2017) conducted a case report in Brugada-type electrocardiographic pattern (n=1). High dose of propafenone was evaluated. A high dose of propafenone in a suicidal attempt caused a Brugada-type electrocardiographic pattern, highlighting the differential diagnosis of Brugada phenocopies.
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