Key result
In African American stroke survivors, class 1 obesity was associated with increased odds of the metabolic syndrome (OR 2.14; 95% CI 1.52-3.01) and poorer blood pressure and glycemic control (P<0.001).
Why the study?
Does increasing BMI associate with higher rates of metabolic syndrome and worse risk factor control in African American stroke survivors?
Observational (n=1,711)
Yes
Does increasing BMI associate with higher rates of metabolic syndrome and worse risk factor control in African American stroke survivors?
In African American stroke survivors, increasing BMI is highly prevalent and strongly associated with the metabolic syndrome and poorer control of blood pressure and blood glucose.
Answers are grounded in this paper and cite their sources.
Obesity management should be prioritized in African American stroke survivors; extends evidence on BMI-linked vascular risks in this population.
BACKGROUND: The rates of obesity and the metabolic syndrome and the impact on traditional vascular risk factors in African American stroke survivors are unknown. OBJECTIVE: To describe the relationships between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and hypertension, dyslipidemia, and diabetes mellitus. DESIGN: We classified 1711 subjects as underweight (BMI, <18.5), normal (BMI, 18.5-24.9), overweight (BMI, 25.0-29.9), or obesity class 1 (BMI, 30.0-34.9), 2 (BMI, 35.0-39.9), or 3 (BMI, >40.0). We compared the proportions with hypertension, dyslipidemia, and diabetes mellitus and control of these factors by clinical history and results of physical examination and laboratory analysis across BMI groups. SETTING: Multicentered clinical trial. PATIENTS: African American subjects with previous ischemic stroke. MAIN OUTCOME MEASURES: Rates of obesity and the metabolic syndrome, odds ratios (ORs) of associated vascular risk factors at baseline, and relationship to longitudinal risk factor control. RESULTS: Overall, 76% were overweight or obese (70% of men and 81% of women). Hypertension, dyslipidemia, and diabetes mellitus were all present in 43.3% of men and 29.1% of women with obesity class 3. The ORs for having the metabolic syndrome were 2.14 (95% confidence interval [CI], 1.52-3.01) for class 1, 1.92 (95% CI, 1.26-2.91) for class 2, and 1.98 (95% CI, 1.27-3.09) for class 3 obesity. In addition, increasing BMI was negatively associated with systolic (P<.001) and diastolic (P<.001) blood pressure and glycemic control (P<.001). CONCLUSION: Our analysis of the data from the African American Antiplatelet Stroke Prevention Study supports the association of increasing risk factor profiles with increasing weight in African American stroke survivors.
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Sean Ruland (2005) conducted an observational in Previous ischemic stroke (n=1,711). Increasing body mass index (BMI) vs. Normal weight (BMI 18.5-24.9) was evaluated on Presence of the metabolic syndrome (OR 2.14, 95% CI 1.52-3.01). In African American stroke survivors, class 1 obesity was associated with increased odds of the metabolic syndrome (OR 2.14; 95% CI 1.52-3.01) and poorer blood pressure and glycemic control (P<0.001).
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