Key result
Nitric oxide stimulates endothelial cell proliferation and mobility in the absence of sGC, but increased intracellular cGMP following sGC activation greatly amplifies its angiogenic potential.
Nitric oxide can stimulate endothelial cell proliferation and migration independently of sGC, but sGC activation greatly amplifies its angiogenic potential.
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Cell culture data on NO/sGC pathways in RAEC are hypothesis-generating; leaves open translation to postnatal angiogenesis.
Pyriochou et al. (2007) studied Angiogenesis. Nitric oxide donor (sodium nitroprusside) and sGC activator (BAY 41-2272) vs. Control was evaluated on Endothelial cell proliferation and migration. Nitric oxide stimulates endothelial cell proliferation and mobility in the absence of sGC, but increased intracellular cGMP following sGC activation greatly amplifies its angiogenic potential.
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