Key result
Propranolol prolonged the phase 2 ventilatory response time constant during exercise in hypoxia (61.3 s vs 31.0 s) and hyperoxia (106.0 s vs 40.2 s) compared to placebo.
Why the study?
Does propranolol alter the ventilatory responses to hypoxic and hyperoxic exercise in healthy human subjects?
Population
5 healthy human subjects
Comparison
Propranolol 120 mg oral dose vs Placebo
Design
Other
Authors
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May alter exercise ventilatory dynamics after beta-blockade; leaves open adrenergic role in human chemoreflex control.
RCT (n=5)
Does propranolol alter the ventilatory responses to hypoxic and hyperoxic exercise in healthy human subjects?
Absolute Event Rate: 61.3% vs 31%
Beta-adrenergic blockade with propranolol slows the dynamics of the ventilatory response to exercise in both hypoxia and hyperoxia, likely secondary to reduced cardiac output and increased CO2 storage.
Conway et al. (1987) conducted an RCT in Healthy (n=5). Propranolol vs. Placebo was evaluated on Phase 2 ventilatory response time constant in hypoxia. Propranolol prolonged the phase 2 ventilatory response time constant during exercise in hypoxia (61.3 s vs 31.0 s) and hyperoxia (106.0 s vs 40.2 s) compared to placebo.
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