Key result
In new-born lambs, the average increase in minute ventilation to inhaled CO2 was 0.075 l/min/kg/mm Hg PaCO2, with the response slope varying inversely with arterial oxygen tension.
Why the study?
Does inhaled CO2 with and without hypoxia affect minute ventilation in new-born lambs?
Population
20 unanaesthetized new-born lambs aged 4 hr-10 days
Design
Preclinical
Authors
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Early post-natal acid-base correction in lambs warrants cautious neonatal monitoring; leaves open translation to human respiratory control.
Does inhaled CO2 with and without hypoxia affect minute ventilation in new-born lambs?
In new-born lambs, the carotid chemo-receptors are involved in the respiratory response to inhaled CO2, and hypoxia potentiates this response.
M. J. Purves (1966) studied Respiratory response to inhaled CO2 and hypoxia (n=20). Inhaled CO2 with and without accompanying hypoxia vs. Baseline or without hypoxia was evaluated on Increase in minute ventilation. In new-born lambs, the average increase in minute ventilation to inhaled CO2 was 0.075 l/min/kg/mm Hg PaCO2, with the response slope varying inversely with arterial oxygen tension.
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