Key result
Hypoxic laryngeal stimulation in piglets demonstrated that laryngeal chemoreflex response severity is significantly associated with changes in arterial PaO2 and hydrogenated hemoglobin saturation (P<0.001).
Population
34 piglets
Design
Preclinical
Authors
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Hypoxia may modulate laryngeal chemoreflex severity in neonates; leaves open translation from piglet models to clinical practice.
p-value: p=<0.001
In a piglet model, the respiratory response to hypoxia predicts the severity of the laryngeal chemoreflex response, with resumption of respiration associated with accumulation of arterial PaCO2.
Yolanda D. Heman‐Ackah (2005) studied Laryngeal chemoreflex response under hypoxic conditions (n=34). Hypoxic laryngeal stimulation vs. Mild, moderate, and profound responders was evaluated on Change in arterial PaO2 and hydrogenated hemoglobin saturation during the LCR-induced response (p=<0.001). Hypoxic laryngeal stimulation in piglets demonstrated that laryngeal chemoreflex response severity is significantly associated with changes in arterial PaO2 and hydrogenated hemoglobin saturation (P<0.001).
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