Key result
Elevated prestimulation pCO2 and low prestimulation pH predicted a profound (fatal) laryngeal chemoreflex response to laryngeal stimulation under normoxic conditions in newborn piglets (P<0.05).
Population
80 newborn piglets (67 evaluated under normoxic conditions)
Design
Preclinical
Authors
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Hypothesis-generating for acid-base status as a modifier of fatal neonatal reflexes; leaves open human translation and clinical relevance.
Observational (n=80)
p-value: p=<.05
In newborn piglets, the combination of an elevated prestimulation pCO2 and a low prestimulation pH predicts a profound, potentially fatal laryngeal chemoreflex response under normoxic conditions.
Heman‐Ackah et al. (2009) conducted an observational in Laryngeal chemoreflex (n=80). Laryngeal stimulation under normoxic conditions was evaluated on Prestimulation pCO2 and pH differences by response severity (p=<.05). Elevated prestimulation pCO2 and low prestimulation pH predicted a profound (fatal) laryngeal chemoreflex response to laryngeal stimulation under normoxic conditions in newborn piglets (P<0.05).