Why the study?
Does acute mild hypoxia reinforce the bradycardic and apneic components of the laryngeal reflex in high-risk infants?
Population
12 infants, aged 5 days-28 weeks, who had sustained an apparent life-threatening event or were siblings of…
Comparison
Pharyngeal water instillation during acute, mild… vs Pharyngeal water instillation during normoxia
Design
Other
Authors
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Hypoxia may amplify laryngeal reflex apnea and bradycardia in infants; hypothesis-generating for SIDS mechanisms, requiring prospective validation.
Does acute mild hypoxia reinforce the bradycardic and apneic components of the laryngeal reflex in high-risk infants?
Acute mild hypoxia significantly reinforces the bradycardic and apneic responses to laryngeal reflex activation in infants, which may be relevant to the pathophysiology of sudden infant death syndrome.
Wennergren et al. (1989) studied this question.
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