Why the study?
Does laryngeal instillation of water or cow's milk induce lethal apnea in animal models?
Population
32 anaesthetized piglets 1 to 42 days of age, 2 3-day-old lambs, and 2 ewes
Comparison
Instillation of distilled water or cow's milk… vs Instillation of normal saline
Design
Preclinical
Follow-up
Approximately 50 minutes
Authors
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Laryngeal chemoreflex data in animals leave open a SIDS mechanism; human studies needed before any clinical relevance.
Does laryngeal instillation of water or cow's milk induce lethal apnea in animal models?
Laryngeal chemosensitivity to water and cow's milk induces a lethal apneic reflex in young animal models, suggesting a possible mechanism for Sudden Infant Death Syndrome.
Downing et al. (1975) studied this question.
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